October 7, 20257 min ReadLast reviewed December 31, 2025

Blepharitis Eye Drops & Care Products

Navigating the pharmacy aisle can be overwhelming. Here is what to look for-and what to avoid-when choosing eye drops and care products for blepharitis.

Preservative-free eye drop bottle and clean eye-care accessories.
D
Dr Awais Rauf
Ophthalmologist, CCT (Ophth) UK
Reviewed by Dr Awais Rauf
Medically Reviewed

While hygiene is the foundation of blepharitis management, some supportive products may improve comfort while you address lid inflammation. The best choice depends on symptoms, drop frequency, sensitivities, and clinician advice. Using the wrong products can make inflammation worse.

Explore this topic: Visit the Blepharitis treatments (UK) hub for step-by-step options.

Eye drops for blepharitis

The best eye drops for blepharitis focus on comfort and surface protection. They do not cure the condition, but they reduce irritation while you treat the lid margin.

1. Artificial Tears / Lubricants

Blepharitis often coexists with tear-film instability, especially with meibomian gland dysfunction, but not everyone has the same pattern. Lubricating drops help stabilize the tears and soothe the ocular surface.

The Golden Rule: Always choose Preservative-Free (PF) drops if possible. Frequent exposure to some preservatives (including BAK) can irritate the ocular surface in some people; preservative-free options are often preferred for frequent use.

Many standard eye drops contain preservatives like Benzalkonium Chloride (BAK). While effective at keeping the bottle sterile, frequent exposure to some preservatives (including BAK) can irritate the ocular surface in some people.

Single-dose preservative-free vials beside a multi-dose bottle with a sterile filter cap.

Side-by-side: Single-dose vials vs. multi-dose bottle with ABA filter.

  • Look for: Single-dose vials or multi-dose bottles with special "ABA" or "COMOD" filters that prevent backflow bacteria.
  • Ingredients: Hyaluronic Acid (Sodium Hyaluronate) is a gold-standard ingredient for its ability to retain water and may support surface health, but it is not a cure.

2. Ointments for Night Time

If you wake up with very dry, gritty eyes, a lubricating ointment or gel used just before bed can be a game-changer. These are thicker than drops and will blur your vision, so they are only for sleep. They provide a physical barrier preventing the eyes from drying out if your eyelids don't close fully (lagophthalmos).

3. Antiseptic Sprays (Hypochlorous Acid)

Hypochlorous acid (HOCl) is a naturally occurring molecule produced by our white blood cells to fight bacteria.

Hypochlorous-acid lid sprays may help reduce lid-margin microbial load and are often well tolerated, but evidence and individual benefit vary. Stop if stinging/irritation occurs and avoid getting spray directly into the eye.

4. Omega-3 Supplements

Diet plays a role in the quality of the oil your meibomian glands produce.

Omega-3 supplements may help some people with dry-eye symptoms, but results across studies are mixed. If you choose to try them, discuss dose and interactions (especially if you take anticoagulants) with your clinician, and consider food sources as an alternative.

  • Source matters: Triglyceride-form fish oils are generally better absorbed than ethyl ester forms. Flaxseed oil is a plant alternative but may be less efficient at conversion in the body.
  • Dosage: Dosing should be individualized; discuss dose and interactions with a clinician and consider dietary sources.

What to Avoid

Whitening Drops (Vasoconstrictors)

Decongestant "get-the-red-out" drops can worsen dryness/irritation in some people and do not treat blepharitis. Lubricants and lid-margin management are usually more appropriate.

Quick answers

FAQs

Short, practical answers to common questions patients ask.

Evidence-led guidance, written for patients.
Expand any question to see the full answer.
What are the best eye drops for blepharitis?
Start with preservative-free lubricating drops, ideally with ingredients like hyaluronic acid to soothe the surface.
Should I use preservative-free eye drops?
Yes, especially if you use drops more than about four times a day or are sensitive to preservatives.
Can eye drops make blepharitis worse?
Yes. Whitening drops or heavily preserved products can irritate the surface and worsen inflammation.
Are gel drops or ointments better at night?
Thicker gels or ointments can help overnight but may blur vision, so use them at bedtime.
How often can I use lubricating drops?
As needed for comfort. Preservative-free drops are safest for frequent use.

Scientific References

  1. Gomes JAP, et al. TFOS DEWS II Iatrogenic Report. Ocul Surf. 2017.
  2. Karakus S, et al. Effects of Omega-3 Fatty Acids on Tear Film and Ocular Surface Parameters in Patients with Meibomian Gland Dysfunction. Cornea. 2018.
  3. Guy's and St Thomas' NHS Foundation Trust. Dry eye syndrome treatment.[Source]